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GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts

✍ Scribed by Gang Xu; Hideaki Kaneto; Maria D. Lopez-Avalos; Gordon C. Weir; Susan Bonner-Weir

Book ID
116405527
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
217 KB
Volume
73
Category
Article
ISSN
0168-8227

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## Abstract Exendin‐4 (EX‐4), a long acting agonist of GLP‐1, induces an endocrine phenotype in Capan‐1 cells. Under culture conditions which include serum, ∼10% of the cells contain insulin and glucagon. When exposed to EX‐4 (0.1 nM, up to 5 days), the number of cells containing insulin and glucag