GLP-1 (9–36) Amide, Cleavage Product of GLP-1 (7–36) Amide, Is a Glucoregulatory Peptide
✍ Scribed by Dariush Elahi; Josephine M. Egan; Richard P. Shannon; Graydon S. Meneilly; Ashok Khatri; Joel F. Habener; Dana K. Andersen
- Book ID
- 109969111
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 279 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1930-7381
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A potent glycogenic effect of GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and specific receptors for this peptide, which do not seem to be associated with the adenylate cyclase-CAMP system, have been detected in these tissue membranes. On the other hand, inositolphosphogl
Intravenous GLP-1 [7-36 amide] can normalize fasting hyperglycaemia in Type 2 diabetic patients. Whether GLP-1 [7-37] has similar effects and how quickly plasma glucose concentrations revert to hyperglycaemia after stopping GLP-1 is not known. Therefore, 8 patients with Type 2 diabetes (5 female, 3
## Background: The insulinotropic hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (7-36 amide) (glp-1), regulate insulin secretion to nutrient intake and constitute the endocrine arm of the entero-insular axis. glucagon has been implicated in the pathophysio