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GLOSSI: a method to assess the association of genetic loci-sets with complex diseases

✍ Scribed by High-Seng Chai; Hugues Sicotte; Kent R Bailey; Stephen T Turner; Yan W Asmann; Jean-Pierre A Kocher

Book ID
114998620
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
501 KB
Volume
10
Category
Article
ISSN
1471-2105

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We set out to apply conventional analytic methods to a GAW data set of nuclear families with an oligogenic disease that has a population prevalence of 0.023. We chose methods generally applied to disorders with at least one major gene. Our approaches included: 1) complex segregation analysis under t