Glomerular filtration rate: Assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney

✍ Scribed by Laurence Annet; Laurent Hermoye; Frank Peeters; François Jamar; Jean-Paul Dehoux; Bernard E. Van Beers

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 312 KB
• Volume: 20
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.20173

✦ Synopsis

Abstract

Purpose

To describe the use of MRI and a cortical‐compartment model to measure the glomerular filtration rate (GFR), and compare the results with those obtained with the Patlak‐Rutland model.

Materials and Methods

Dynamic MRI of rabbit kidneys was performed during and after injection of gadoterate dimeglumine. The enhancement curves in the aorta and the kidney were analyzed with the cortical‐compartment and Patlak‐Rutland models to assess the GFR.

Results

A substantial correlation was observed between the GFR measured with MRI using the cortical‐compartment model and the plasma clearance of 51Cr‐EDTA (r = 0.821, P = 0.004). No significant correlation was observed between the 51Cr‐EDTA clearance (r = 0.628, P = 0.052) and the GFR obtained with the Patlak‐Rutland model in regions of interest (ROIs) encompassing the renal cortex and medulla. A Bland and Altman analysis showed that GFR~cortical~ ~compartment~ agreed better with the 51Cr‐EDTA clearance compared to GFR~Patlak~ when ROIs were limited to the cortex. However, the GFR values obtained by MRI were lower than the plasma clearance of 51Cr‐EDTA.

Conclusion

MRI with a cortical‐compartment model provides more accurate assessments of glomerular filtration than the Patlak‐Rutland model. J. Magn. Reson. Imaging 2004;20:843–849. © 2004 Wiley‐Liss, Inc.