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Glomerular epithelial cells transform to myofibroblasts: early but not late removal of TGF-β1 reverses transformation

✍ Scribed by Ramin Sam; Linda Wanna; Krishnamurthy P. Gudehithlu; Sandra L. Garber; George Dunea; Jose A.L. Arruda; Ashok K. Singh

Book ID: 119383091
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 975 KB
Volume: 148
Category: Article
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2006.04.003

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The effects of TGF beta 1 on cell cycle events in a rat liver derived epithelial cell line (BL9) and in two in vitro transformants of this line were studied by flow cytometry. Using either ethidium bromide staining or the incorporation of bromodeoxyuridine to evaluate DNA synthesis it was shown that