๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

GLOBAL TESTS FOR COMBINATION DRUG STUDIES IN FACTORIAL TRIALS

โœ Scribed by H. M. JAMES HUNG

Book ID
102650249
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
759 KB
Volume
15
Category
Article
ISSN
0277-6715

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โœฆ Synopsis

To test the hypothesis that there are some studied dose combinations more effective in treating a disease than their respective component doses of two drugs, Hung, Chi and Lipicky proposed two a-level tests for normally distributed data. This paper extends the utilities of these tests to the outcome variable that has variance as a function of its mean, such as with a binomially distributed outcome, and to incomplete factorial design settings where some cells are not studied. I explore the impacts of excluding cells from study on the power performances of these tests.

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## Objective: To evaluate global statistical tests (gsts) of treatment effectiveness for rheumatoid arthritis (ra) trials measuring multiple outcomes. ## Methods: Using outcome measures from american college of rheumatology (acr) core set variables available in 3 ra trials, gsts were calculated u