𝔖 Bobbio Scriptorium
✦   LIBER   ✦

GLOBAL TESTS FOR ANALYSIS OF MULTIPLE TUMOUR DATA FROM ANIMAL CARCINOGENICITY EXPERIMENTS

✍ Scribed by JAMES J. CHEN

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
659 KB
Volume
15
Category
Article
ISSN
0277-6715

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✦ Synopsis

This paper presents test procedures for testing of the overall dose effect at every tumour type/site simultaneously in a chronic animal carcinogenicity bioassay. I derive global tests of the tumour prevalence rates and the tumour onset rates using the generalized estimating equations approach. The test is based on the model of a common dose effect alternative. I used the logistic regression model for simultaneous testing of non-lethal tumours, and the Poly-3 test for testing of mixtures of lethal or non-lethal tumours of different types/sites. An application illustrating the proposed tests concerns analysis of a carcinogenicity experiment designed to study the dose response of hepatocellular and bladder tumours to 2-acetylaminofluorene (2-AAF) exposure.

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