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Global Proteomics Analysis of Acrolein Adducts in Human Airway Epithelial Cells in Vitro

✍ Scribed by Page C. Spiess; Bin Deng; Dwight E. Matthews; Albert van der Vliet

Book ID: 113631435
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 369 KB
Volume: 49
Category: Article
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2010.10.227

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## Abstract Acrolein is an environmental pollutant that is also derived endogenously through lipid peroxidation and protein degradation. The reaction of acrolein with 2′‐deoxyguanosine produces exocyclic 1,__N__^2^‐propano‐2′‐deoxyguanosine (AdG) adducts, mutagenic lesions that play important roles