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Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets

✍ Scribed by P. Ylipaasto; B. Kutlu; S. Rasilainen; J. Rasschaert; K. Salmela; H. Teerijoki; O. Korsgren; R. Lahesmaa; T. Hovi; D. L. Eizirik; T. Otonkoski; M. Roivainen

Publisher
Springer
Year
2005
Tongue
English
Weight
550 KB
Volume
48
Category
Article
ISSN
0012-186X

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## Abstract Cytokines produced by immune system cells infiltrating pancreatic islets are candidate mediators of islet beta‐cell destruction in autoimmune insulin‐dependent diabetes mellitus. After 72 h exposure of human pancreatic islets to a cytotoxic cytokine combination of interleukin 1 beta (50