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Global increase in DNA methylation in patients with myelodysplastic syndrome

✍ Scribed by Metzig, K; Göhring, G; Schlegelberger, B; Länger, F; Kreipe, H; Lehmann, U; Römermann, D; Hasemeier, B

Book ID
109886818
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
126 KB
Volume
22
Category
Article
ISSN
0887-6924

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## Abstract Lynch syndrome is an inherited disease resulting predominantly in colorectal cancer (CRC). The crucial cause is DNA mismatch repair (MMR) malfunction that is associated mostly with __MLH1__ or __MSH2__ germline mutations. A significant hallmark of repair defects is a high level of insta