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Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism

✍ Scribed by Jeanette N. McClintick; David W. Crabb; Huijun Tian; Jane Pinaire; Jennifer R. Smith; Ronald E. Jerome; Howard J. Edenberg

Book ID
108187240
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
163 KB
Volume
17
Category
Article
ISSN
0955-2863

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## Abstract The antiepileptic drug phenobarbital (PB) is used frequently as a model tumor promoter in rodent liver. It is believed to increase the probability of cancer by accelerating the clonal expansion of cells transformed during tumor initiation. The molecular mechanism underlying this process