Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors
β Scribed by Netto, Georges J; Nakai, Yasutomo; Nakayama, Masashi; Jadallah, Sana; Toubaji, Antoun; Nonomura, Norio; Albadine, Roula; Hicks, Jessica L; Epstein, Jonathan I; Yegnasubramanian, Srinivasan
- Book ID
- 109887552
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 353 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0893-3952
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## Abstract ## BACKGROUND: There is an increasing body of literature associating testicular microlithiasis (TM), a common finding on testicular ultrasound, with testicular germ cell tumor (TGCT) and intratubular germ cell neoplasia of unclassified type (ITGCNU). Determining these associations is p
## Abstract Mutations in the __KIT__ gene occur in βΌ8% of all testicular germ cell tumors (TGCT) and __KIT__ is the most frequently mutated known cancer gene. One report has shown that 93% of patients with bilateral disease have a mutation at codon 816 of the __KIT__ gene. Importantly, this suggest