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Global DNA hypomethylation in breast carcinoma : Correlation with prognostic factors and tumor progression

✍ Scribed by Jorge Soares; António E. Pinto; Celso V. Cunha; Saudade André; Isabel Barão; J. Meneses Sousa; Marília Cravo

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
94 KB
Volume
85
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

The global DNA methylation of 136 breast lesions (117 primary invasive carcinomas, 5 benign phyllodes tumors, 11 fibroadenomas, and 3 sclerosing adenosis) and their respective adjacent parenchyma was analyzed using an in vitro enzyme assay.

METHODS.

In the group of patients with breast carcinoma, DNA hypomethylation was correlated with clinical and pathologic parameters known to affect disease prognosis. Histopathologic type, disease stage, and tumor grade were evaluated according to the World Health Organization classification, the TNM system, and the criteria of Elston and Ellis' criteria, respectively. DNA flow cytometry was performed in fresh/frozen samples stained with propidium iodide. Hormone receptor (estrogen and progesterone receptor) status was determined by immunocytochemistry.

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