Global control of cell-cycle transcription by coupled CDK and network oscillators

CDK inhibitors selectively diminish cell

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

✍ Partha Mitra; Prachi N. Ghule; Margaretha van der Deen; Ricardo Medina; Rong-lin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 593 KB

## Abstract Cell cycle progression into S phase requires the induction of histone gene expression to package newly synthesized DNA as chromatin. Cyclin E stimulation of CDK2 at the Restriction point late in G1 controls both histone gene expression by the p220^NPAT^/HiNF‐P pathway and initiation of