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Gliotoxin induces caspase-dependent neurite degeneration and calpain-mediated general cytotoxicity in differentiated human neuroblastoma SH-SY5Y cells

✍ Scribed by V. Axelsson; S. Holback; M. Sjögren; H. Gustafsson; A. Forsby


Book ID
116292947
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
154 KB
Volume
345
Category
Article
ISSN
0006-291X

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Calpains have importance in human neurodegenerative disease pathogenesis, but these mechanisms are difficult to study in postmortem tissues. To establish a cellular model of the human calpain and calpastatin system, we characterized calpain I, calpain II, and calpastatin in SH-SY5Y human neuroblasto