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Glioma cell sensitivity to topotecan: the role of p53 and topotecan-induced DNA damage

✍ Scribed by Friederike Schmidt; Johannes Rieger; Jörg Wischhusen; Ulrike Naumann; Michael Weller


Book ID
114013639
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
166 KB
Volume
412
Category
Article
ISSN
0014-2999

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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh