𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Glial fibrillary acidic protein-expressing cells in the neurogenic regions in normal and injured adult brains

✍ Scribed by Hong Zhu; Annica Dahlström

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
775 KB
Volume
85
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In the adult brain, neurogenic stem cells are prevalent in the subventricular zone (SVZ) of the lateral ventricle wall and the subgranular zone (SGZ) in the dentate gyrus. Cells that have structural and molecular characteristics of astrocytes function as neurogenic stem cells in these regions, in which these cells also participate in the creation of the microenvironment that stimulates neurogenesis. In the present paper, we review the phenotypic properties, subpopulations, and proliferation of glial fibrillary acidic protein (GFAP)‐expressing cells in these two neurogenic regions and their responses to different brain injuries. Cells fulfilling the criteria for astrocytes, i.e., expressing GFAP, in the SVZ and SGZ respond differently to brain injuries or neurogenic stimuli. The importance of guidance by astrocytes of newly formed neuronal cells is emphasized. The assessment of GFAP‐expressing cells in the neurogenic regions is of great importance for understanding the mechanism underlying the response of neural stem cells to brain injury. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Quercetin inhibits c-fos, heat shock pro
Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes
✍ Bing Yi Wu; Albert Cheung Hoi Yu 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 398 KB

Quercetin, a bioflavonoid, is found widely in many kinds of fruits and vegetables. It is known to engage in many bioactivities, such as interfering with of the progress of stress responses to injury. In the present study, we investigated the effects of quercetin on some injury responses in primary c

Extracellular potassium influences DNA a
Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells
✍ Karen S. Canady; Francis Ali-Osman; Edwin W. Rubel 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 731 KB

Previous reports of increases in glial cell number and expression of glial fibrillary acidic protein (GFAP) in stimulated brain regions or epileptic tissue have implicated a role for increases in extracellular potassium concentration ([EL+],) in glial reactions. We examined the effects of altered [K

Hormones and growth factors induce the s
Hormones and growth factors induce the synthesis of glial fibrillary acidic protein in rat brain astrocytes
✍ R. S. Morrison; Dr. J. De Vellis; Y. L. Lee; R. A. Bradshaw; L. F. Eng 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 647 KB

Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a c

Methylprednisolone inhibits the expressi
Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes
✍ Wei-Lin Liu; Yi-Hsuan Lee; Shih-Ying Tsai; Chung Yi Hsu; Yu-Yo Sun; Liang-Yo Yan 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 444 KB

## Abstract Reactive gliosis caused by post‐traumatic injury often results in marked expression of chondroitin sulfate proteoglycan (CSPG), which inhibits neurite outgrowth and regeneration. Methylprednisolone (MP), a synthetic glucocorticoid, has been shown to have neuroprotective and anti‐inflamm