Glial cell line–derived neurotrophic factor–levodopa interactions and reduction of side effects in parkinsonian monkeys
✍ Scribed by Yasuyuki Miyoshi; Zhiming Zhang; Aliza Ovadia; Paul A. Lapchak; Frank Collins; Dana Hilt; Carl Lebel; Richard Kryscio; Dr. Don M. Gash
- Book ID
- 102706610
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 712 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0364-5134
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Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neurotrophic effects on motor neurons as well as mesencephalic dopaminergic neurons. Because GDNF promotes survival of motor neurons in vivo and in vitro and rescues motor neurons from naturally occurring cell death, the pote
## Abstract The physiological roles of glial cell line‐derived neurotrophic factor (GDNF) expressed in the microglia/macrophages of the injured spinal cord have not yet been clarified. mRNA expression of chemokines, including monocyte chemoattractant protein (MCP)‐1, was evoked within 1 hr after tr