Glial cell line-derived neurotrophic factor protects against delayed neuronal death after transient forebrain ischemia in rats
β Scribed by H Miyazaki; Y Okuma; Y Fujii; K Nagashima; Y Nomura
- Book ID
- 117492795
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 294 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0306-4522
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We investigated whether certain hydrophobic dipeptides, LeuβIle, LeuβPro, and ProβIle, which partially resemble the site on FK506 that binds to immunophilin, could stimulate glial cell lineβderived neurotrophic factor (GDNF) and brainβderived neurotrophic factor (BDNF) synthesis in cult
The expression of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B are both increased after global ischemia. Therefore, a protective action of BDNF against the delayed degeneration of vulnerable neurons has been suggested. We have investigated the neuroprotective action of