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Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells

✍ Scribed by Z.-Y Chen; Y.-F Chai; L Cao; A.-J Huang; R.-Y Cui; C.-L Lu; C He

Book ID
117490108
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
109 KB
Volume
104
Category
Article
ISSN
0306-4522

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## Abstract The ability of microglia to produce/secrete glial cell line–derived neurotrophic factor (GDNF) in vitro was examined. Immunoblotting analysis revealed that nonstimulated microglia release limited amounts of GDNF with molecular sizes of 14 and 17 kDa. However, the secreted amounts signif