Glial cell line-derived neurotrophic factor: Characterization of mammalian posttranslational modifications
β Scribed by Piccinini, Elisa; Kalkkinen, Nisse; Saarma, Mart; Runeberg-Roos, Pia
- Book ID
- 118250493
- Publisher
- Informa plc
- Year
- 2012
- Tongue
- English
- Weight
- 666 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0785-3890
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Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenerg
## Abstract Much attention has been paid to the ability of glial cell lineβderived neurotrophic factor (GDNF) to protect neurons from neurotoxic insults in the central nervous system (CNS). However, little is known about GDNF action on CNS glia that also can express GDNF receptor systems. In this s