𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Glia-induced neuronal differentiation by transcriptional regulation

✍ Scribed by Christian Göritz; Renaud Thiebaut; Luc-Henri Tessier; Katja Nieweg; Christoph Moehle; Isabelle Buard; Jean-Luc Dupont; Leon J. Schurgers; Gerd Schmitz; Frank W. Pfrieger

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
290 KB
Volume
55
Category
Article
ISSN
0894-1491

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

There is increasing evidence that different phases of brain development depend on neuron–glia interactions including postnatal key events like synaptogenesis. To address how glial cells influence synapse development, we analyzed whether and how glia‐derived factors affect gene expression in primary cultures of immunoisolated rat retinal ganglion cells (RGCs) by oligonucleotide microarrays. Our results show that the transcript pattern matched the developmental stage and characteristic properties of RGCs in vitro. Glia‐conditioned medium (GCM) and cholesterol up‐ and downregulated a limited number of genes that influence the development of dendrites and synapses and regulate cholesterol and fatty acid metabolism. The oligonucleotide microarrays detected the transcriptional regulation of neuronal cholesterol homeostasis in response to GCM and cholesterol treatment. Surprisingly, our study revealed neuronal expression and glial regulation of matrix gla protein (Mgp). Together, our results suggest that glial cells promote different aspects of neuronal differentiation by regulating transcription of distinct classes of genes. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The nutritive function of glia is regula
The nutritive function of glia is regulated by signals released by neurons
✍ Marco Tsacopoulos; Carol L. Poitry-Yamate; Serge Poitry; Philippe Perrottet; Ann 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB

The idea of a metabolic coupling between neurons and astrocytes in the brain has been entertained for about 100 years. The use recently of simple and well-compartmentalized nervous systems, such as the honeybee retina or purified preparations of neurons and glia, provided strong support for a nutrit

Regulation of osteoblast differentiation
Regulation of osteoblast differentiation by transcription factors
✍ Toshihisa Komori 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

## Abstract Runx2, osterix, and β‐catenin are essential for osteoblast differentiation. Runx2 directs multipotent mesenchymal cells to an osteoblastic lineage, and inhibits them from differentiating into the adipocytic and chondrocytic lineages. After differentiating to preosteoblasts, β‐catenin, o

Regulation of in vitro glia-induced micr
Regulation of in vitro glia-induced microvessel morphogenesis by urokinase
✍ John Laterra; Ravi R. Indurti; Gary W. Goldstein 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 893 KB

Plasminogen activators (PAS) regulate a variety of processes involved in tissue morphogenesis and differentiation. We used a coculture system in which microvascular endothelial cells are induced by glial cells to form capillary-like structures in order to examine the role of urokinase-type PA (uPA)

BMP and FGF-2 regulate neurogenin-2 expr
BMP and FGF-2 regulate neurogenin-2 expression and the differentiation of sensory neurons and glia
✍ Mitsunori Ota; Kazuo Ito 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 618 KB

## Abstract We have examined the effects of signaling molecules and Notch signaling on the mechanisms regulating neurogenin (ngn) ‐2 expression. This ngn‐2 is a transcription factor that is essential for the specification of early differentiating sensory neurons in the dorsal root ganglia. In the p

Neuronal activity rapidly induces transc
Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo
✍ Aaron S. Nudelman; Derek P. DiRocco; Talley J. Lambert; Michael G. Garelick; Jos 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 364 KB

## Abstract Activity‐dependent changes in gene‐expression are believed to underlie the molecular representation of memory. In this study, we report that in vivo activation of neurons rapidly induces the CREB‐regulated microRNA miR‐132. To determine if production of miR‐132 is regulated by neuronal

Regulation of brain-derived neurotrophic
Regulation of brain-derived neurotrophic factor transcripts by neuronal activation in rat hypothalamic neurons
✍ Frédéric Marmigère; Florence Rage; Lucia Tapia-Arancibia 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 346 KB

## Abstract Brain‐derived neurotrophic factor (BDNF) belongs to the neurotrophin family and regulates the survival, differentiation, and maintenance of function in different neuronal populations. BDNF is strongly expressed in hypothalamic neurons, where it exerts long‐ or short‐lasting actions. Bec