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GLI2 mutations in four Brazilian patients: How wide is the phenotypic spectrum?

✍ Scribed by Fedik Rahimov; Lucilene Arilho Ribeiro; Eziquiel de Miranda; Antonio Richieri-Costa; Jeffrey C. Murray


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
412 KB
Volume
140A
Category
Article
ISSN
1552-4825

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✍ Renato P. Munhoz; Yosuke Wakutani; Connie Marras; Helio A. Teive; Salmo Raskin; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB

## Abstract Mutations in the Leucine‐Rich Repeat Kinase 2 gene (__LRRK2__) are mainly responsible for idiopathic Parkinson's disease (PD) with either a dominant pattern of transmission or a sporadic occurrence due to the reduced penetrance. A majority of __LRRK2__ kindreds demonstrate an extremely