GLC-mass spectrometry of several important anticancer drugs I: Pertrimethylsilylation and O-methoxime formation

✍ Scribed by Eric Watson; Kenneth K. Chan

• Book ID: 102406961
• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 449 KB
• Volume: 67
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600670914

✦ Synopsis

Procedures are reported for the formation of pertrimethylsilyl and pertrimethylsilyl methoxime derivatives of the aglycones of doxorubicin, daunorubicin, carminomycin, chromomycin A3, and mithramycin. The mass spectra are consistent with the formation of these derivatives. Fragmentation patterns highly specific for these derivatives are proposed, and the potential application for the identification of metabolites of these compounds is discussed.