## Abstract ## Objective To determine whether glatiramer acetate (GA) slows accumulation of disability in primary progressive multiple sclerosis. ## Methods A total of 943 patients with primary progressive multiple sclerosis were randomized to GA or placebo (PBO) in this 3โyear, doubleโblind tri
Glatiramer acetate in combination with minocycline in patients with relapsing--remitting multiple sclerosis: results of a Canadian, multicenter, double-blind, placebo-controlled trial
โ Scribed by Metz, L.; Li, D.; Traboulsee, A.; Myles, M.; Duquette, P.; Godin, J.; Constantin, M.; Yong, V.
- Book ID
- 118029835
- Publisher
- SAGE Publications
- Year
- 2009
- Tongue
- English
- Weight
- 317 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1352-4585
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## Abstract ## Objective Rituximab, a monoclonal antibody selectively depleting CD20+ B cells, has demonstrated efficacy in reducing disease activity in relapsingโremitting multiple sclerosis (MS). We evaluated rituximab in adults with primary progressive MS (PPMS) through 96 weeks and safety thro
## Abstract Two prior doubleโblind, placeboโcontrolled, randomized trials demonstrated that glatiramer acetate (GA) reduces relapse rates in patients with relapsing remitting multiple sclerosis (RRMS). This study was designed to determine the effect, onset, and durability of any effect of GA on dis