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Gilbert and Crigler Najjar syndromes: An update of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene mutation database

✍ Scribed by Canu, Giulia; Minucci, Angelo; Zuppi, Cecilia; Capoluongo, Ettore


Book ID
123156983
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
275 KB
Volume
50
Category
Article
ISSN
1079-9796

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Uridine-diphosphoglucuronate glucuronosyltransferases (UGTs) are a family of enzymes that conjugate various endogenous and exogenous compounds with glucuronic acid and facilitate their excretion in the bile. Bilirubin-UGT(1) (UGT1A1) is the only isoform that significantly contributes to the conjugat