From cytogenetic and immunohistochemical findings in a primary giant cell fibmarcoma and its recurrence, it is further demonstrated that a close relationship exists between this tumor and dermatofibrosarcoma protuberans. Both tumors express CD34 and show rearrangements of chromosomes I 7 and 2 2 Gen
Giant cell fibroblastoma. A juvenile form of dermatofibrosarcoma protuberans
โ Scribed by Barry M. Shmookler; Franz M. Enzinger; Sharon W. Weiss
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 1023 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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## Abstract Giant cell fibroblastoma (GCF) is a subcutaneous mesenchymal neoplasm characterized by the chromosomal t(17;22), which results in the formation of the fusion gene __COL1A1โPDGFB__. This same fusion gene is also seen in the supernumerary ring chromosome of dermatofibrosarcoma protuberans
Dermatofibrosarcoma protuberans (DFSP) and its juvenile form, giant-cell fibroblastoma (GCF), are uncommon infiltrative tumors of the dermis, which present unique cytogenetic features, such as the reciprocal translocation t(17;22) or, more commonly, supernumerary ring chromosomes containing sequence