GI drug absorption in rats exposed to cobalt-60 γ-radiation III: In situ intestinal absorption

Absorption barriers in the rat intestina

Absorption barriers in the rat intestinal mucosa: 1. application of an in situ perfusion model to simultaneously assess drug permeation and metabolism

✍ Daniel R. Mudra; Ronald T. Borchardt 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB 👁 1 views

Modulation of intestinal drug absorption barriers can have a profound impact on the bioavailability of orally administered compounds. With its commonality of use as an absorption model, it is valuable to assess the role of such barriers in the rat intestinal mucosa. In the present study, atenolol an