Ghrelin (Endocrine Updates)

✍ Scribed by Ezio Ghigo

• Year: 2004
• Tongue: English
• Leaves: 270
• Edition: 1
• Category: Library

✦ Synopsis

Ghrelin is a 28-amino acid acylated peptide predominantly produced by the stomach. It displays strong GH-releasing activity mediated by the hypothalamus-pituitary GH secretagogue (GHS)-receptors specific for synthetic GHS. Ghrelin also acts on other central and peripheral receptors and enables other actions including: stimulation of lactotroph and corticotroph secretion; food-intake; gastro-entero-pancreatic functions; metabolic; cardiovascular activity; and anti-proliferative effects. This volume aims to highlight the impact and function of the hormone ghrelin and provide insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.

✦ Table of Contents

Contents......Page 6
List of Contributors......Page 8
Preface......Page 12
1. Historical Milestones......Page 14
2. Discovery of Ghrelin‚ an Endogenous Ligand for the Growth-Hormone Secretagogue Receptor......Page 28
3. Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands......Page 40
4. Ghrelin: A New Link Between the Neuroendocrine Control of the GH Axis‚ Food Intake and Sleep......Page 60
5. Growth Hormone Releasing Activity of Ghrelin......Page 74
6. Non-Growth Hormone Endocrine Actions of Ghrelin......Page 86
7. Ghrelin Food Intake and Energy Balance......Page 104
8. Cardiovascular Activities of Ghrelin and Synthetic GHS......Page 126
9. Ghrelin: Central Actions and Potential Implications in Neuro-Degenerative Diseases......Page 136
10. Ghrelin and Tumors......Page 156
11. Metabolic Actions of Ghrelin......Page 178
12. Gastro-Entero-Pancreatic Actions of Ghrelin......Page 192
13. A New Interaction to Come: Ghrelin and Steroid Hormones......Page 208
14. Circulating Ghrelin Levels in Pathophysiological Conditions......Page 220
15. Ghrelin Measurement: Present and Perspectives......Page 238
16. Ghrelin: Implications in Pediatric Endocrinology......Page 250
17. Ghrelin and its Analogues: Perspectives for a Story of Reverse Pharmacology......Page 262
G......Page 268
N......Page 269
W......Page 270