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Germline variations of the MALT1 gene as risk factors in the development of primary gastric B-cell lymphoma

✍ Scribed by Stephan Hellmig; Tobias Bartscht; Wolfgang Fischbach; Stephan Johannes Ott; Philip Rosenstiel; Wolfram Klapper; Ulrich Robert Fölsch; Stefan Schreiber


Book ID
116430014
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
156 KB
Volume
45
Category
Article
ISSN
0959-8049

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Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3-MALT1 and IGH-MALT1 respectively, and activate the NF-kappaB pathway. Among 122 diffuse large B-