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Germline TP53 R337H mutation is not sufficient to establish Li-Fraumeni or Li-Fraumeni-like syndrome

✍ Scribed by Raul C. Ribeiro; Carlos Rodriguez-Galindo; Bonald C. Figueiredo; Maria Jose Mastellaro; Alina Nico West; Richard Kriwacki; Gerard P. Zambetti

Book ID
116334225
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
88 KB
Volume
247
Category
Article
ISSN
0304-3835

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πŸ“œ SIMILAR VOLUMES

Association of germline or somatic TP53
Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndrome
✍ Waka Sugawara; Yasuhito Arai; Fumio Kasai; Yuiko Fujiwara; Masayuki Haruta; Rie πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 700 KB

## Abstract Germline __TP53__ mutations are found in Li‐Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies. The mutations and succeeding genetic events are thought to cause LFS‐associated cancer, whose genetic alterations have rarely been investigated. Here,