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Germline PMS2 Mutations: One Hit or Two?

✍ Scribed by Robert Gryfe; Steven Gallinger


Book ID
119758506
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
88 KB
Volume
128
Category
Article
ISSN
0016-5085

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Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o