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Germline Mutations in SMAD4 Disrupt Bone Morphogenetic Protein Signaling

✍ Scribed by Jennifer C. Carr; Fadi S. Dahdaleh; Donghong Wang; James R. Howe

Book ID: 116707845
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 129 KB
Volume: 174
Category: Article
ISSN: 0022-4804
DOI: 10.1016/j.jss.2011.11.008

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## Abstract Prostate cancer is the most commonly diagnosed malignancy in men and is often associated with bone metastases. Prostate cancer bone lesions can be lytic or schlerotic, with the latter predominating. Bone morphogenetic proteins (BMPs) are a family of growth factors, which may play a role