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Germline mutations in DNA repair and cell cycle checkpoint genes: consequential somatic gene alterations and genome instability

โœ Scribed by S Ingvarsson


Book ID
120701185
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
185 KB
Volume
5
Category
Article
ISSN
1465-5411

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DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have be