Germline and somatic mutation analyses i
โ
Steven M. Lipkin; Victoria Wang; Dan L. Stoler; Garth R. Anderson; Ilan Kirsch;
๐
Article
๐
2001
๐
John Wiley and Sons
๐
English
โ 262 KB
๐ 2 views
DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC). Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have be