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Germline KRAS mutations cause Noonan syndrome

✍ Scribed by Schubbert, Suzanne; Zenker, Martin; Rowe, Sara L; Böll, Silke; Klein, Cornelia; Bollag, Gideon; van der Burgt, Ineke; Musante, Luciana; Kalscheuer, Vera; Wehner, Lars-Erik

Book ID: 109919325
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 251 KB
Volume: 38
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng1748

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## Abstract Noonan syndrome (NS) is the most common non‐chromosomal syndrome seen in children and is characterized by short stature, dysmorphic facial features, chest deformity, a wide range of congenital heart defects and developmental delay of variable degree. Mutations in the Ras/mitogen‐activat