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Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate Cancer

✍ Scribed by Annika Rökman; Tarja Ikonen; Eija H. Seppälä; Nina Nupponen; Ville Autio; Nina Mononen; Joan Bailey-Wilson; Jeffrey Trent; John Carpten; Mika P. Matikainen; Pasi A. Koivisto; Teuvo L.J. Tammela; Olli-P. Kallioniemi; Johanna Schleutker

Book ID
117853906
Publisher
American Society of Human Genetics
Year
2002
Tongue
English
Weight
167 KB
Volume
70
Category
Article
ISSN
0002-9297

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✍ Alain Latil; Patrice Morant; Georges Fournier; Philippe Mangin; Philippe Berthon 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 217 KB

## Abstract Loss of heterozygosity (LOH) at chromosome 13q14 is one of the most recurrent anomalies observed in sporadic prostate tumors. This LOH is believed to unmask recessive mutations that inactivate a tumor‐suppressor gene(s) which otherwise regulates normal cell growth and suppresses abnorma