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Germ-line and somatic mutations of the APC gene in patients with turcot syndrome and analysis of APC mutations in brain tumors

✍ Scribed by Takahiro Mori; Hiroki Nagase; Akira Horii; Yasuo Miyoshi; Shuichi Nakatsuru; Takahisa Aoki; Hirofumi Arakawa; Yusuke Nakamura; Takashi Shimano; Akio Yanagisawa; Yukitaka Ushio; Sadamu Takano; Michio Ogawa; Masato Nakamura; Masabumi Shibuya; Ryo Nishikawa; Masao Matsutani; Yasuhide Hayashi; Hitoshi Takahashi; Fusahiro Ikuta; Tetsuro Nishihira; Shozo Mori

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 453 KB
Volume: 9
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870090304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The Turcot syndrome (TS) is a rare, probably autosomal recessive, disorder characterized by development of primary neuroepithelial tumors of the central nervous system (CNS) and numerous adenomatous colorectal polyps. To examine the possible involvement of mutations of the APC gene, which is responsible for familial adenomatous polyposis (FAP), in Turcot syndrome, we examined DNAs from TS patients for alterations in this gene by means of ribonuclease protection analysis. Germ‐line APC mutations were detected in each of three unrelated cases of TS, and additional (somatic) mutations were observed in colonic adenomas that had developed in one of these patients. However, no somatic mutations in APC were found among 91 neuroepithelial tumors (medulloblastoma, glioblastoma, astrocytoma, and oligodendroglioma). whether sporadic or associated with TS. These results suggest that the APC gene is associated with pathogenesis of one feature of TS, but that at least one other gene is responsible for the genesis of neuroepithelial tumors in the CNS. Genes Chrom Cancer 9:168‐172 (1994). © 1994 Wiley‐Liss, Inc.

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