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Germ cell function and hormonal status in patients with testicular cancer

✍ Scribed by Peter Vejby Hansen; Henrik Trykker; Jørn Andersen; Poul Erik Helkjær

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
611 KB
Volume
64
Category
Article
ISSN
0008-543X

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✦ Synopsis

Sperm counts, serum gonadotropins, and androgen levels were investigated in 39 seminoma patients and 58 patients with a nonseminomatous germ cell tumor of the testis after unilateral orchiectomy. In 58% of the patients, the total sperm count was below the lower reference value (80 million). A multiregression analysis demonstrated a correlation between a decreased total sperm count and the following three explanatory variables: (1) an elevated serum alpha-fetoprotein (AFP), (2) a history of chryptorchidism, or (3) a seminomatous tumor. In 42% of the patients, the sperm concentration and the sperm motility met criteria considered sufficient for cryopreservation. Serum follicle-stimulating hormone (FSH) was elevated in 33% of the patients. Androgens (serum testosterone or urine 17-oxy-steroids (17-0s)) were subnormal in 5% of the patients, whereas serum luteinizing hormone (LH) was elevated in 14% of the patients without human chorionic gonadotropin @-subunit (8-HCG) in serum.

Cancer 64:956-961, 1989.

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