Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes
β Scribed by Masaki Yoda; Tadahiro Sakai; Hirohito Mitsuyama; Hideki Hiraiwa; Naoki Ishiguro
- Book ID
- 106234038
- Publisher
- Springer Japan
- Year
- 2011
- Tongue
- English
- Weight
- 354 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0949-2658
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## Abstract Chondrocyte apoptosis has been implicated in the pathogenesis of osteoarthritis. Transglutaminase 2 (TG2), the expression of which is higher in osteoarthritis patients, has been shown to be upβregulated during apoptosis in many experimental models. This study investigated the expression
The primary objective of this study was to test the hypothesis that inhibition of mitochondrial permeability transition and/or inhibition of caspase family enzymes can block chondrocyte apoptosis induced by H2O2. Primary human chondrocytes were isolated from normal cartilage by enzymatic digestion.