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Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes

✍ Scribed by Masaki Yoda; Tadahiro Sakai; Hirohito Mitsuyama; Hideki Hiraiwa; Naoki Ishiguro


Book ID
106234038
Publisher
Springer Japan
Year
2011
Tongue
English
Weight
354 KB
Volume
16
Category
Article
ISSN
0949-2658

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## Abstract Chondrocyte apoptosis has been implicated in the pathogenesis of osteoarthritis. Transglutaminase 2 (TG2), the expression of which is higher in osteoarthritis patients, has been shown to be up‐regulated during apoptosis in many experimental models. This study investigated the expression

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The primary objective of this study was to test the hypothesis that inhibition of mitochondrial permeability transition and/or inhibition of caspase family enzymes can block chondrocyte apoptosis induced by H2O2. Primary human chondrocytes were isolated from normal cartilage by enzymatic digestion.