Geodiamolides H and I, further cyclodepsipeptides from the marine sponge Geodia sp

✍ Scribed by Winston F. Tinto; Alan J. Lough; Stewart McLean; William F. Reynolds; Margaret Yu; Wilfred R. Chan

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 326 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)00157-4

✦ Synopsis

Two new cyclodepsipeptides, geodiamolide H (3) and I (4), were isolated from the marine sponge Geodia sp. The structures of 3 and 4 were determined by 2D NMR spectroscopy while the absolute stereochemistry of 4 was established by X-ray crystallography. Geodiamolide H 3 was cytotoxic to some human cancer cell lines.