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Gentamicin pharmacokinetics in old age and frailty

โœ Scribed by Sarah N. Hilmer; Kim Tran; Patrick Rubie; Jason Wright; Danijela Gnjidic; Sarah J. Mitchell; Slade Matthews; Peter R. Carroll


Book ID
108642634
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
741 KB
Volume
71
Category
Article
ISSN
0306-5251

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Age-dependent nephrotoxicity and the pha
โœ R. Marre; N. Tarara; T. Louton; K. Sack ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Springer ๐ŸŒ English โš– 410 KB

The pharmacokinetics and nephrotoxicity of gentamicin were studied in female Wistar rats of different ages. I.m. administration of 5 mg of gentamicin/kg revealed that young rats (90g) had lower peak serum levels and a prolonged elimination half-life, when compared with adult animals. After repeated