Genotyping of the Spanish cystic fibrosis population at the ΔF508 mutation site and RFLP linked loci
✍ Scribed by B. Jaume-Roig; B. Simon-Bout; A. Taillandier; J. L. Serre; J. Antich; J. Bellon; J. Boué; A. Boué
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 201 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0340-6717
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## Abstract In Causasian populations cystic fibrosis (CF) is the most common autosomal recessive disorder. CF was previously considered rare in Mexico; however, the reported frequency is about 1% in autopsies. This discrepancy appears to be due to the inability to diagnose the illness during life.
In the present paper, we applied surface plasmon resonance (SPR) and biosensor technologies for biospecific interaction analysis (BIA) to detect DF508 mutation (F508del) of the cystic fibrosis transmembrane regulator (CFTR) gene in both homozygous as well as heterozygous human subjects. The proposed