Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase
✍ Scribed by Mikael Oscarson; Harriet Gullstén; Arja Rautio; Maria Luisa Bernal; Blanca Sinues; Marja-Liisa Dahl; Jari H Stengård; Olavi Pelkonen; Hannu Raunio; Magnus Ingelman-Sundberg
- Book ID
- 117109929
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 107 KB
- Volume
- 438
- Category
- Article
- ISSN
- 0014-5793
No coin nor oath required. For personal study only.
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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to
The hepatic cytochrome P4502A6 (CYP2A6) enzyme mediates the oxidative metabolism of several procarcinogens that have liver as their primary target. Mouse models indicate that liver tumors invariably overexpress CYP2A forms, and that inflammation and cirrhosis may regulate the CYP2A expression patter