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Genotyping of frameshift mutations in early and metastatic colorectal cancer with microsatellite instability

✍ Scribed by Laghi, Luigi; Bianchi, Paolo; Orbetegli, Ombretta; Heinimann, Karl; Rossetti, Carto; Doci, Roberto; Gennari, Leandro; Roncalli, Massimo; Malesci, Alberto


Book ID
124124845
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
178 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Abstract Microsatellite instability characterizes a sub‐set of sporadic colorectal cancers (CRCs) as well as CRCs from patients with hereditary non‐polyposis colorectal cancer (HNPCC). In order to clarify when the cells acquire a replication‐error phenotype (RER) during colorectal‐tumor progress