Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population
✍ Scribed by Catherine Spire-Vayron de la Moureyre; Hervé Debuysere; Bruno Mastain; Elizabeth Vinner; Delphine Marez; Jean-Marc Lo Guidice; Dany Chevalier; Serge Brique; Kokou Motte; Jean-Frédéric Colombel; Dominique Turck; Christian Noel; René-Marc Flipo; Annie Pol; Michel Lhermitte; Jean-Jacques Lafitte; Christian Libersa; Franck Broly
- Book ID
- 110003916
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 331 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0007-1188
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📜 SIMILAR VOLUMES
To detect mutations in the thiopurine S-methyltransferase gene (TPMT), we have developed a strategy based on single-strand conformation polymorphism (SSCP) analysis of the gene amplified by polymerase chain reaction (PCR). The sensitivity of the method was first evaluated by analyzing DNA samples fr