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Genotypic and Phenotypic Analyses of Hepatitis C Virus Variants Observed in Clinical Studies of VX-222, a Nonnucleoside NS5B Polymerase Inhibitor

✍ Scribed by Jiang, M.; Zhang, E. Z.; Ardzinski, A.; Tigges, A.; Davis, A.; Sullivan, J. C.; Nelson, M.; Spanks, J.; Dorrian, J.; Nicolas, O.; Bartels, D. J.; Rao, B. G.; Rijnbrand, R.; Kieffer, T. L.


Book ID
127276654
Publisher
American Society for Microbiology
Year
2014
Tongue
English
Weight
716 KB
Volume
58
Category
Article
ISSN
0066-4804

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The NS5A replication complex inhibitor, BMS-790052, inhibits hepatitis C virus (HCV) replication with picomolar potency in preclinical assays. This potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a 14-day multiple-ascending dose (MAD) monotherapy stu