Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse

✍ Scribed by Simona Cabib; Stefano Puglisi-Allegra

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 252 KB
• Volume: 97
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00442243

✦ Synopsis

The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the same strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.