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Genotype by sex interaction in measures of lipids, lipoproteins, and apolipoproteins

✍ Scribed by Dr. Bradford Towne; John Blangero; Roger M. Siervogel

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
347 KB
Volume
10
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Genotype by sex (GxS) interaction in a quantitative trait indicates that the sexual dimorphism exhibited in that trait is heritable. GxS interaction has implications for the modeling oftraits in segregation analyses and for the assessment of disease risk in males and females. Thirteen quantitative measures of lipids, lipoproteins, and apolipoproteins from 203 to 301 individuals in 25 to 27 kindreds were examined for evidence of GxS interaction. These measures included serum concentrations of total cholesterol, triglycerides, LDL-C, HDL-C, apo B, and apo AI, and peak LDL particle diameter, small LDL mass, large LDL mass, IDL mass, VLDL mass, HDL, mass, and HDL, mass. GxS interaction was indicated for transformed values of LDL-C and small LDL mass by an additive genetic correlation between males and females significantly less than 1.0, and GxS interaction was indicated for transformed values of HDL, mass and HDL, mass by males and females having significantly different additive genetic variances.

1993 Wiley-Liss, Inc.

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Genotype-by-sex (G Γ— S) interaction refers to the interaction of autosomal genes with male or female physiological "environments." G Γ— S interaction has been demonstrated in quantitative genetic analyses of a variety of traits including serum lipid concentrations and anthropometrics, and the importa