The industrial solvent N-methyl-2-pyrrolidinone (NMP) and its hydrolysis product, 4-(methylamino)butanoic acid (N-MeGABA), were examined for mutagenicity and cytotoxicity in the Ames Salmonella/microsome assay. In order to detect a broad range of possible mutagenic endpoints, the following strains w
✦ LIBER ✦
Genotoxicity of 5-aminolevulinic and 4,5-dioxovaleric acids in the salmonella/microsuspension mutagenicity assay and SOS chromotest
✍ Scribed by Janice Onuki; Célia Maria Rech; Marisa H.G. Medeiros; Gisela de A. Umbuzeiro; Paolo Di Mascio
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 130 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.10083
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The chlorinated drinking water mutagen 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) occurs at concentrations similar to or greater than that of the related furanone 3-chloro-4-(dichloromethyl)-5hydroxy-2(5H)-furanone (MX). MCF and MX differ structurally only by replacement of a 3-methyl in MCF w