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Genomically humanized mice: technologies and promises

✍ Scribed by Devoy, Anny; Bunton-Stasyshyn, Rosie K. A.; Tybulewicz, Victor L. J.; Smith, Andrew J. H.; Fisher, Elizabeth M. C.

Book ID: 109953509
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 468 KB
Volume: 13
Category: Article
ISSN: 1471-0056
DOI: 10.1038/nrg3116

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## Abstract Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (